Tabelle
| # | Mannschaft | Spiele | S | U | N | T | GT | TD | P |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Bayern Munich | 5 | 4 | 1 | 0 | 20 | 4 | +16 | 13 |
| 2 | Wolfsburg | 5 | 4 | 1 | 0 | 7 | 2 | +5 | 13 |
| 3 | Borussia Dortmund | 5 | 4 | 0 | 1 | 17 | 11 | +6 | 12 |
| 4 | Bayer Leverkusen | 5 | 3 | 1 | 1 | 15 | 7 | +8 | 10 |
| 5 | Mainz | 5 | 3 | 1 | 1 | 6 | 2 | +4 | 10 |
| 6 | Freiburg | 5 | 2 | 3 | 0 | 6 | 4 | +2 | 9 |
| 7 | FC Cologne | 5 | 2 | 2 | 1 | 9 | 7 | +2 | 8 |
| 8 | Union Berlin | 5 | 1 | 3 | 1 | 7 | 8 | -1 | 6 |
| 9 | Hertha Berlin | 5 | 2 | 0 | 3 | 7 | 12 | -5 | 6 |
| 10 | Hoffenheim | 5 | 1 | 2 | 2 | 8 | 7 | +1 | 5 |
| 11 | Augsburg | 5 | 1 | 2 | 2 | 2 | 8 | -6 | 5 |
| 12 | RB Leipzig | 5 | 1 | 1 | 3 | 6 | 7 | -1 | 4 |
| 13 | Arminia Bielefeld | 5 | 0 | 4 | 1 | 3 | 5 | -2 | 4 |
| 14 | Stuttgart | 5 | 1 | 1 | 3 | 9 | 12 | -3 | 4 |
| 15 | Eintracht Frankfurt | 5 | 0 | 4 | 1 | 5 | 8 | -3 | 4 |
| 16 | Borussia M'gladbach | 5 | 1 | 1 | 3 | 5 | 9 | -4 | 4 |
| 17 | Bochum | 5 | 1 | 0 | 4 | 4 | 13 | -9 | 3 |
| 18 | Greuther Fürth | 5 | 0 | 1 | 4 | 3 | 13 | -10 | 1 |
Spiele
| 24/09/2021 | ||
| Greuther Fürth | 20:30 | Bayern Munich |
| 25/09/2021 | ||
| Union Berlin | 15:30 | Arminia Bielefeld |
| Hoffenheim | 15:30 | Wolfsburg |
| RB Leipzig | 15:30 | Hertha Berlin |
| Bayer Leverkusen | 15:30 | Mainz |
| Eintracht Frankfurt | 15:30 | FC Cologne |
| Borussia M'gladbach | 18:30 | Borussia Dortmund |
| 26/09/2021 | ||
| Bochum | 15:30 | Stuttgart |
| Freiburg | 17:30 | Augsburg |
| 01/10/2021 | ||
| FC Cologne | 20:30 | Greuther Fürth |
| 02/10/2021 | ||
| Borussia Dortmund | 15:30 | Augsburg |
| Wolfsburg | 15:30 | Borussia M'gladbach |
| Stuttgart | 15:30 | Hoffenheim |
| Hertha Berlin | 15:30 | Freiburg |
| RB Leipzig | 18:30 | Bochum |
| 03/10/2021 | ||
| Mainz | 15:30 | Union Berlin |
| Bayern Munich | 17:30 | Eintracht Frankfurt |
| Arminia Bielefeld | 19:30 | Bayer Leverkusen |
| 15/10/2021 | ||
| Hoffenheim | 20:30 | FC Cologne |
Ergebnisse
| 19/09/2021 | ||
| Wolfsburg | 1 - 1 | Eintracht Frankfurt |
| Borussia Dortmund | 4 - 2 | Union Berlin |
| Stuttgart | 1 - 3 | Bayer Leverkusen |
| 18/09/2021 | ||
| FC Cologne | 1 - 1 | RB Leipzig |
| Arminia Bielefeld | 0 - 0 | Hoffenheim |
| Augsburg | 1 - 0 | Borussia M'gladbach |
| Mainz | 0 - 0 | Freiburg |
| Bayern Munich | 7 - 0 | Bochum |
| 17/09/2021 | ||
| Hertha Berlin | 2 - 1 | Greuther Fürth |
| 12/09/2021 | ||
| Borussia M'gladbach | 3 - 1 | Arminia Bielefeld |
| Bochum | 1 - 3 | Hertha Berlin |
| Eintracht Frankfurt | 1 - 1 | Stuttgart |
| 11/09/2021 | ||
| RB Leipzig | 1 - 4 | Bayern Munich |
| Greuther Fürth | 0 - 2 | Wolfsburg |
| Hoffenheim | 0 - 2 | Mainz |
| Freiburg | 1 - 1 | FC Cologne |
| Union Berlin | 0 - 0 | Augsburg |
| Bayer Leverkusen | 3 - 4 | Borussia Dortmund |
| 29/08/2021 | ||
| Wolfsburg | 1 - 0 | RB Leipzig |
| Union Berlin | 2 - 1 | Borussia M'gladbach |
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